GPR40: A therapeutic target for mediating insulin secretion

Autor:	Qian-Li Tang, Xiao-Tao Feng, Wei Zhao, Zhen Xie, Shuang-Lei Li, Jing Leng
Rok vydání:	2012
Předmět:	endocrine system Oncogene Cell General Medicine Type 2 diabetes Biology Pharmacology Cell cycle medicine.disease Molecular medicine medicine.anatomical_structure Free fatty acid receptor 1 Diabetes mellitus Genetics medicine Cancer research Receptor
Zdroj:	International Journal of Molecular Medicine. 30:1261-1266
ISSN:	1791-244X 1107-3756
DOI:	10.3892/ijmm.2012.1142
Popis:	G-protein-coupled receptor 40 (GPR40), known as free fatty acid receptor 1, is mainly expressed in pancreatic β-cells and activated by medium- and long-chain fatty acids. Increasing evidence indicates that the activation of GPR40 in cells causes insulin secretion, and GPR40 has become an attractive therapeutic target for type 2 diabetes. Recently, certain novel GPR40 agonists have been identified that regulate glucose-stimulated insulin secretion, leading to the development of new drugs for the treatment of type 2 diabetes. In this review, we focus on progress in the physiological role of GPR40 and potential drugs targeting GPR40 over the past decade.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::434b74f45c3aefe255069738e36829a0 https://doi.org/10.3892/ijmm.2012.1142 Zobrazit plný text záznamu