Crystal structure and antimicrobial activity of a transplatin adduct of N,N′-dimethylthiourea, trans-[Pt(NH3)2(dmtu)2]Cl2
| Autor: | Abdul Rahman Al-Arfaj, Anvarhusein A. Isab, Tanzeel Khalid, Muhammad Saleem, Islam Ullah Khan, Saeed Ahmad, Ejaz, Muhammad Aziz Choudhary, Tobias Rüffer, Seerat-ur-Rehman |
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| Rok vydání: | 2016 |
| Předmět: |
biology
010405 organic chemistry Stereochemistry Aspergillus niger chemistry.chemical_element General Chemistry Crystal structure 010402 general chemistry biology.organism_classification Antimicrobial 01 natural sciences 0104 chemical sciences Adduct chemistry.chemical_compound Minimum inhibitory concentration chemistry Penicillium citrinum Platinum Cis–trans isomerism |
| Zdroj: | Monatshefte für Chemie - Chemical Monthly. 148:669-674 |
| ISSN: | 1434-4475 0026-9247 |
| DOI: | 10.1007/s00706-016-1809-4 |
| Popis: | The crystal structure of a transplatin-derived complex, trans-[Pt(NH3)2(dmtu)2]Cl2 (dmtu = N,N ’ -dimethylthiourea) was determined by X-ray crystallography and its antimicrobial activities were evaluated by minimum inhibitory concentration. The structure consists of trans-[Pt(NH3)2(dmtu)2]2+ cation and two chloride ions. In trans-[Pt(NH3)2(dmtu)2]2+, the geometry at platinum is nearly regular square planar with the average cis and trans angles of 90 and 178.6°, respectively. The 1H and 13C NMR spectral data indicated the coordination of both ligands to platinum(II). The results of antimicrobial studies showed that the complex exhibited significant activity against gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa), while relatively poor activities were observed against molds (Aspergillus niger, Penicillium citrinum) and yeasts (Candida albicans, Saccharomyces cerevisiae). |
| Databáze: | OpenAIRE |
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