Antiproliferative response induced Euphorbia umbellata fractions and subfractions in melanoma and hepatocellular carcinoma tumor cells

Autor:	Thalles Anthony Duarte Oliveira, Durvanei Augusto Maria, Rosa Andrea Nogueira Laiso, Thais de Oliveira Conceição, Monique Gonçalves Alves, Amanda Gomes, Laertty Garcia de Sousa Cabral
Rok vydání:	2020
Předmět:	Confluency medicine.anatomical_structure Chemistry Melanoma Hepatocellular carcinoma Toxicity medicine Cancer research Cytotoxic T cell Depolarization Fibroblast medicine.disease Inner mitochondrial membrane
Zdroj:	Journal of Pharmacognosy and Phytochemistry. 9:32-40
ISSN:	2278-4136 2349-8234
Popis:	Resistance to the therapies currently offered for melanoma and hepatocellular carcinoma requires new research that seeks more effective therapeutic agents with less toxicity. The present study aimed to evaluate the antiproliferative, antitumor effects and the modulation of the mitochondrial electrical potential of the Acetate and Chloroform fractions and the sub-fractions Methanol, Ethanol, Dichloromethane and Ether, isolated from E. umbellata latex sap in murine melanoma cells (B16 -F10), hepatocellular carcinoma tumor cells (Hepa1c1c7) and normal fibroblast cells (FN1). The Acetate and Chloroform fractions showed significantly cytotoxic potential for tumor cells B16-F10 and Hepa1c1c7, in addition to the fractions being sensitive to the ether and methanol compounds. Such compounds promoted the reduction of cell confluence, the modulation of mitochondrial electrical potential, the depolarization of the mitochondrial membrane, and the release of pro-apoptotic mechanisms that resulted in the death of both tumor lines.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::433ea61df2a1847c6e5d20e6056f8fa7 https://doi.org/10.22271/phyto.2020.v9.i5a.12392 Zobrazit plný text záznamu