Regioselective N-methyl carbon lithiation of N-boc-methylalkylamines. Expedient synthesis of unsymmetrical amines

Autor:	Mark Rogers-Evans, Victor Snieckus, Won Koo Lee, Freskos John N, Peter Beak, E. K. Yum
Rok vydání:	1994
Předmět:	chemistry.chemical_compound Methyl carbon chemistry Organic Chemistry Drug Discovery Electrophile Regioselectivity Organic chemistry Alkylation Aliphatic compound Biochemistry Methyl group
Zdroj:	Tetrahedron Letters. 35:4067-4070
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(00)73113-3
Popis:	The regioselective lithiation and functionalization at the N -methyl group of N- t -Boc-N-methylalkylamines 3 and 5 are shown with a variety of electrophiles to give products 4 and 6 , respectively, thus providing a convenient methodology for the elaboration of unsymmetrical amines.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::433c10d631a9c6f1b952afe42d1b737b https://doi.org/10.1016/s0040-4039(00)73113-3 Zobrazit plný text záznamu