| Autor: |
Dmitry Budker, Shoujun Xu, Louis-S. Bouchard, D. J. Michalak, C. W. Crawford, David E. Wemmer, Thomas J. Lowery, Alexander Pines, M. P. Ledbetter |
| Rok vydání: |
2011 |
| Předmět: |
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| Zdroj: |
Magnetic Resonance in Medicine. 66:603-606 |
| ISSN: |
0740-3194 |
| Popis: |
Laser atomic magnetometry is a portable and low-cost yet highly sensitive method for low magnetic field detection. In this work, the atomic magnetometer was used in a remote-detection geometry to measure the relaxivity of aqueous gadolinium-diethylenetriamine pentaacetic acid Gd(DTPA) at the Earth's magnetic field (40 μT). The measured relaxivity of 9.7±2.0 s(-1) mM(-1) is consistent with field-cycling experiments measured at slightly higher magnetic fields, but no cryogens or strong and homogeneous magnetic field were required for this experiment. The field-independent sensitivity of 80 fT Hz(-1/2) allowed an in vitro detection limit of ∼10 μM Gd(DTPA) to be measured in aqueous buffer solution. The low detection limit and enhanced relaxivity of Gd-containing complexes at Earth's field motivate continued development of atomic magnetometry toward medical applications. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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