Nonspecific leukocytolysisin vitro as a test of comparative cytotoxicity of low-molecular nonelectrolytes

Autor:	A. P. Vorotyntsev, M. P. Vavilov, E. K. Nazarova, E. A. Luzhnikov
Rok vydání:	1995
Předmět:	chemistry.chemical_compound Chromatography Chemistry Dimethyl sulfoxide Urea Glycerol Tonicity General Medicine Cytotoxicity Osmosis General Biochemistry Genetics and Molecular Biology In vitro Osmolar Concentration
Zdroj:	Bulletin of Experimental Biology and Medicine. 119:165-167
ISSN:	1573-8221 0007-4888
DOI:	10.1007/bf02445867
Popis:	In experiments with hypo-, iso-, and hypertonic solutions taken at equimolar concentrations for equilibrium of osmotic conditions the leukocytolytic action of each of three nonelectrolytes was shown to be a parabolic function of osmotic concentrations. The comparative degree of leukocytolysis for urea is superior to that for glycerin and glucose and in inverse proportion to their molecular weight. As this difference depends on the chemical component of action, nonspecific leukocytolysisin vitro is considered as a test of comparative cytotoxicity in contrast to the specific (immunologic) cytotoxicity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::43338dfb8a3c7b5daa7e4eb1d5b37a4c https://doi.org/10.1007/bf02445867 Zobrazit plný text záznamu Full text from SpringerLink