Abstract P4-05-13: PTEN deletion is linked to adverse phenotype and poor prognosis in breast cancer
| Autor: | Christian Wilke, Patrick Lebok, Albert von der Assen, Volkmar Müller, Fritz Jänicke, Stefan Geist, Annette Lebeau, Eike Burandt, Valerie Kopperschmidt, Anja Mittenzwei, Isabell Witzel, Uwe Heilenkötter, Peter Paluchowski, Ronald Simon, Martina Kluth, Rainer Krech |
|---|---|
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Cancer Research. 75:P4-05 |
| ISSN: | 1538-7445 0008-5472 |
| Popis: | Deletions of chromosome 10q23, including the PTEN (phosphatase and tensin homolog) locus, are known to occur in breast cancer, but systematic analyses of its clinical relevance are lacking. We thus analyzed a tissue microarray (TMA) with 2,197 breast cancers by fluorescence in-situ hybridization (FISH) using a PTEN-specific probe, and found deletions in 19% of no special type, 9% of lobular, 46% of medullary and 4% of tubular cancers. 98.7% of deletions were heterozygous and 1.3% were homozygous. PTEN deletion was significantly linked to advanced tumor stage (p=0.0054), high tumor grade (p Citation Format: Eike Burandt, Martina Kluth, Valerie Kopperschmidt, Anja Mittenzwei, Annette Lebeau, Volkmar Müller, Isabell Witzel, Fritz Jänicke, Stefan Geist, Peter Paluchowski, Christian Wilke, Uwe Heilenkötter, Rainer Krech, Albert von d Assen, Ronald Simon, Patrick Lebok. PTEN deletion is linked to adverse phenotype and poor prognosis in breast cancer [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P4-05-13. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|