Adjuvant activity of chitosan in the design of a vaccine against infectious bovine rhinotracheitis

Autor:	Biotechnology – Mva by K. I. Skryabin, Moscow, Russian Federation, N. V. Pimenov, Zh. Yu. Muradyan, R. V. Rogov
Rok vydání:	2021
Předmět:	business.industry medicine.medical_treatment technology industry and agriculture macromolecular substances Infectious bovine rhinotracheitis equipment and supplies Virology carbohydrates (lipids) Chitosan chemistry.chemical_compound chemistry medicine business Adjuvant
Zdroj:	Veterinariya, Zootekhniya i Biotekhnologiya. 1:29-33
ISSN:	2311-455X
Popis:	The paper presents the results of studying the immunostimulating properties of chitosan in the design of a vaccine against infectious rhinotracheitis in cattle. The optimal concentration of chitosan succinate as an adjuvant of the vaccine against infectious bovine rhinotracheitis was established at 0.5%. At the same time, the optimal interval between immunizations was 21 days. The work shows that the use of chitosan succinate as an adjuvant can significantly increase the level of post-vaccination immunity by 5.33 log2 in rabbits, which indicates the high adjuvant properties of chitosan.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::43226dca76c2c88b2890e510713db32b https://doi.org/10.36871/vet.zoo.bio.202106005 Zobrazit plný text záznamu