Autologous and Allogeneic Tumor Cell Vaccines
| Autor: | E. Nößner, D. J. Schendel |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Antitumor immunity
biology business.industry animal diseases Cancer chemical and pharmacologic phenomena Tumor cells biochemical phenomena metabolism and nutrition Tumor vaccines Major histocompatibility complex medicine.disease Immune system Immunization Antigen Cancer research biology.protein bacteria Medicine business |
| Zdroj: | Gene Therapy ISBN: 9783034870139 |
| DOI: | 10.1007/978-3-0348-7011-5_19 |
| Popis: | The basic principle underlying the development of tumor vaccines is that tumor cells express antigens that enable the immune system to distinguish them from their normal counterparts. Because of other deficiencies, tumor cells are ineffective at initiating specific immune responses. Genetic engineering of tumors can compensate for some deficiencies, thereby enhancing their potential to induce antitumor immunity. Immunization of cancer patients with genetically engineered tumor vaccines should activate lymphocytes that are able to eliminate residual, unmodified tumor cells which themselves would be incapable of inducing an immune response. |
| Databáze: | OpenAIRE |
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