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Background Basal thumb osteoarthritis (OA) can cause significant pain and cause a decline in hand function (Litwic et al 2013). Guidelines for treatment of symptomatic basal thumb OA supports a conservative approach, including splinting to support the carpometacarpal joint (CMCJ) and reduce the painful movements of the thumb joint during functional tasks (Zhang et al 2000). Lack of legitimate placebo thumb splint has been a barrier to research to distinguish the specific mechanism of the perceived therapeutic effect of wearing thumb splints. Despite this, splinting of the basal thumb joint remains a common intervention for pain. This research contributed to a national CRN portfolio adopted study examining the clinical effectiveness and efficacy of basal thumb splints for people with basal thumb OA. Objectives In the present study, the efficacy of two novel placebo splint designs are examined in comparison to widely used verum thumb splint and no splint for the effect at skin surface interface whilst performing a functional task Methods This proof of concept study used a single blind, cross-over design that assessed the effect of wearing different splint conditions on the skin surface interface during a functional hand task. 17 healthy participants (male n=8; female n=9) who met the inclusion criteria were recruited to take part in the study. Skin surface temperature (°C) and pressure exerted at the skin surface interface was recorded during performance of a standardised hand function task, the nine-hole peg test (9HPT) for four splint conditions i) verum splint (Promedics NC79562), ii) placebo lycra splint (P1); iii) placebo lycra splint “lite” (P2) and iv) no splint. Data were recorded and analysed by one rater using MatLab and SPSS software. Results It was observed from the mean rank that the verum splint condition caused the greatest pressures compared to all other splint conditions. Post hoc analysis revealed there was no difference in pressure exerted over the CMCJ between the no splint condition and P1 (Z= -1.577, p=0.115) and P2 (Z= -0.365, p=0.715). The verum splint caused a significant increase in pressure over the CMCJ in comparison to all other test conditions (Z= -3.516, p |