| Autor: |
Odinaka Kelechi Kenneth, Ihenetu Francis Chukwuebuka, Nnadozie Raymond Ikechukwu, Agomo Chimere Obiora, Okoro Chinyere Ihuarulam, Okoro Oluchi Ijeoma, Dunga Kingsly Excell, Iroegbu Uchechi Francis |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
European Journal of Preventive Medicine. 6:58 |
| ISSN: |
2330-8222 |
| DOI: |
10.11648/j.ejpm.20180604.14 |
| Popis: |
Circulating levels of Tumour Necrosis Factor (TNF)-α have been shown to correlate with disease severity in African children. Interleukin 10 (IL-10) production appears to be important in the induction and maintenance of immunity to P. falciparum in naturally exposed populations.TNF-α induces fever, and elevated body temperatures can suppress parasitemia. Although TNF-α-induced mechanisms can serve the host to control infection, prolonged exposure to TNF-α may adversely affect the individual by inducing or promoting severe disease. The present study was conducted among children in Imo State, South Eastern Nigeria between July 2014 and March 2015, with a view to assessing the relationship between Plasmodium falciparum density and the ratio of inter-leukin 10(IL-10) and tumor necrosis factor (TNF-α). Blood samples were taken from children aged 1-72 months with fever or history of fever in the last 24 hours whose caregivers consented to the study.Malaria parasite density was determined by microscopy while the serum and/or plasma levels of cytokine by ELISA method.The geometric mean of IL-10/TNF-α ratios of 1.9pg/ml,2.0pg/ml and 1.3pg/ml were recorded for parasite density groups of 1-1000, 1001 – 10000 and >10,000 parasites/µlrespectively. IL-10/TNF-α ratio significantly decreased at high parasite density group (>10,000 parasites/µl) compared to lower parasite density groups (p=0.008). The IL-10/TNFα ratio in parasitized and healthy control groups were 3.4pg/ml and 1.8 pg/ml, respectively (P |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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