Is a one-week course of triple anti-Helicobacter pylori therapy sufficient to control active duodenal ulcer?

Autor:	Bojan Tepes, Krizman I, M Gorensek, Marija Gubina, I Orel
Rok vydání:	2001
Předmět:	medicine.medical_specialty Intention-to-treat analysis Hepatology biology medicine.drug_class business.industry Gastroenterology Proton-pump inhibitor Helicobacter pylori biology.organism_classification Placebo medicine.anatomical_structure Internal medicine Clarithromycin medicine Duodenum Pharmacology (medical) business Omeprazole medicine.drug Antibacterial agent
Zdroj:	Alimentary Pharmacology & Therapeutics. 15:1037-1045
ISSN:	0269-2813
DOI:	10.1046/j.1365-2036.2001.01020.x
Popis:	Background: Triple therapy currently forms the cornerstone of the treatment of patients with Helicobacter pylori-positive duodenal ulcer. Aim: To establish whether prolonged antisecretory therapy is necessary in patients with active duodenal ulcer. Methods: A total of 77 patients with H. pylori-positive duodenal ulcer were included in a prospective, controlled, double-blind study. All patients received a 7-day treatment with omeprazole 20 mg b.d., clarithromycin 500 mg b.d. and amoxicillin 1000 mg b.d. Patients in the omeprazole group underwent an additional 14-day therapy with omeprazole 20 mg; patients in placebo group received placebo. Endoscopy was performed upon inclusion in the study and after 3 and 8 weeks. Results: Seventy-four patients were eligible for a per protocol analysis after 3 weeks, and 65 after 8 weeks. After 3 weeks, the healing rate was 89% in the omeprazole group and 81% in the placebo group (P=0.51). After 8 weeks, the ulcer healed in 97% of the patients in the total group (95% CI: 92.7–100%). H. pylori was eradicated in 88% of patients in the omeprazole group and in 91% in the placebo group (P=1.0). No statistically significant differences between the groups were found in ulcer-related symptoms or in ulcer healing. Conclusion: In patients with H. pylori-positive duodenal ulcer, a 7-day triple therapy alone is sufficient to control the disease.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::42fe8e67876c55b1ad74c413668d0a6e https://doi.org/10.1046/j.1365-2036.2001.01020.x Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.