The effects of crocin (active contstituent of saffron) treatment on brain antioxidant enzyme mRNA levels in diabetic rats / Diyabetik ratlarda safranın aktif içeriği olan krosin tedavisinin beyindeki antioksidan enzimlerin mRNA seviyeleri üzerine etkisi
| Autor: | Eyup Altinoz, Cemal Ekici, Berna Özyazgan, Yilmaz Cigremis |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification medicine.medical_specialty Messenger RNA Antioxidant Chemistry medicine.medical_treatment Biochemistry (medical) Clinical Biochemistry medicine.disease Biochemistry Crocin 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine Endocrinology Enzyme Mrna level Safranin Internal medicine Diabetes mellitus medicine Molecular Biology 030217 neurology & neurosurgery |
| Zdroj: | Turkish Journal of Biochemistry. 41 |
| ISSN: | 1303-829X 0250-4685 |
| Popis: | Objective: The aim of the present study is to evaluate the effect of crocin on mRNA expression of antioxidant enzymes, SOD, CAT and GPX in the brain of the STZ induced diabetic rats.Methods: Thirty animals randomized in three groups containing ten animals in each group as follows; control (non-diabetic rats), DM (STZ-induced untreated diabetic rats), DM+crocin (STZ-induced diabetic rats treated with crocin,). Crocin was given at a dose of 20 mg/kg bw/day by gavage for 21 days.Results: STZ injection caused a significant increase in mRNA expression of antioxidant enzymes, SOD, CAT and GPX when compared to control group. Crocin given to diabetic rats significantly decreased mRNA expression of antioxidant enzymes, SOD, CAT and GPX when compared to DM group.Conclusion: The present study demonstrates that crocin can modulate mRNA expression of antioxidant enzymes, SOD, CAT and GPX and oxidative stress in the brain of the STZ induced diabetic rats. |
| Databáze: | OpenAIRE |
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