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To study the involvement of age and inflammationin motor colonic activity in man, contractile responsesto CCK, carbachol, and KCl of isolated colonic smoothmuscle cells (SMC) from normal and inflamed human colons were evaluated; the incidence ofsex and smoking on contraction was also analyzed.Contractile responses to the three agonists weresignificantly lower in tissues with a low degree ofinflammation than in tissues with high level of inflammationor normal tissues. This reduction in cell responsivenessappears to be nonspecific and nonreceptor mediated. Apositive correlation of the contractile responses to the three stimulants with the age ofpatients was observed. In contrast, no association wasfound between sex, smoking, and cell contraction. Inconclusion, contractions of SMC due to CCK, carbachol, and KCl were significantly modified duringlife; inflammation of the colon led to a loss of SMCresponsiveness. |
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