| Autor: |
Tige R. Rustad, Courtney R. Plumlee, John D. Aitchison, David R. Sherman, Michael K. Axthelm, Vitaly V. Ganusov, Sara B. Cohen, Caleb R. Stoltzfus, Benjamin H. Gern, Michael Y. Gerner, Fergal J. Duffy, Kevin B. Urdahl, Daniel E. Zak, Scott G. Hansen, Jared L. Delahaye, Louis J. Picker |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
SSRN Electronic Journal. |
| ISSN: |
1556-5068 |
| DOI: |
10.2139/ssrn.3541362 |
| Popis: |
Tuberculosis (TB) is a highly heterogeneous disease that develops in a subset of individuals infected with aerosolized Mycobacterium tuberculosis (Mtb). We sought to develop an improved experimental model by infecting mice with an ultra-low dose (ULD, 1-3 founding Mtb bacteria), which is believed to reflect a physiologic inoculum. ULD-infected mice exhibited bacterial burdens ranging from |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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