Identification of Chemical Compounds from Artemisia gmelinii using UPLC-QTOF-MS/MS and their Regulatory Effects on Immune Responses in DSS-Induced Colitis Mice
| Autor: | In Jin Ha, Saruul Erdenebileg, Chu Won Nho, Ji Min Shin, Sang Min Kim, Yang-Ju Son, Da Seul Jung, Young-Sik Kim |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Chemokine Gastrointestinal tract biology Chemistry Inflammation Spleen General Medicine Pharmacology medicine.disease Inflammatory bowel disease Proinflammatory cytokine 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Immune system Complementary and alternative medicine medicine biology.protein 030211 gastroenterology & hepatology medicine.symptom Colitis |
| Zdroj: | The American Journal of Chinese Medicine. 49:941-963 |
| ISSN: | 1793-6853 0192-415X |
| Popis: | Artemisia gmelinii Web. ex Stechm. (AG), a popular medicinal herb in Asia, has been used as a common food ingredient in Korea and is traditionally known for its anti-inflammatory properties. Therefore, in this study, we aimed to investigate whether AG relieves IBD, a classic chronic inflammatory disease of the gastrointestinal tract. We identified 35 chemical compounds in AG ethanol extract using ultra-high-performance liquid chromatography-quadrupole time-of-flight tandem mass spectrometry. In mice with DSS-induced IBD, AG administration attenuated the disease activity index and the serum and colonic levels of inflammatory cytokines and chemokines. AG treatment decreased nuclear factor-[Formula: see text]B (NF-[Formula: see text]B) signaling, a key mediator of inflammation, in the mouse colons. Additionally, AG extract enhanced immune responses in lymphoid tissues such as spleen and Peyer’s patches. Thus, AG consumption potently ameliorated IBD symptoms and improved immune signaling in lymphoid tissues. |
| Databáze: | OpenAIRE |
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