Synthesis of 5′-C-Branched Thymidines and Conversion to Phosphoramidites

Autor:	Guangyi Wang, Patrick J. Middleton
Rok vydání:	1998
Předmět:	chemistry.chemical_compound Nucleophile Stereochemistry Chemistry Genetics Thymidine Biochemistry
Zdroj:	Nucleosides and Nucleotides. 17:1033-1051
ISSN:	0732-8311
DOI:	10.1080/07328319808004219
Popis:	Thymidine was converted to its 5′-epoxy derivative, which was reacted with nucleophiles to give 5′-C-aminomethyl-, 5′-C-bromomethyl-, 5′-C-cyanomethyl, and 5′-C-methoxymethylthymidine derivatives with defined stereochemistry. 5′-C-ally-, 5′-C-hydroxymethyl-, 5′-C-hydroxypropyl-, and 5′-C-(imidazole-4-acetamido)methyl-thymidine derivatives were also prepared. The 5′-C-branched thymidines were converted to the corresponding phosphoramidites.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::42e61a0963c6ad3ebbca0090b1101dbd https://doi.org/10.1080/07328319808004219 Zobrazit plný text záznamu