| Autor: |
E. I. Akural, P. Ranta, Seppo Alahuhta, P. Volmanen, Aydin Tekay, P. Ohtonen, T. Raudaskoski |
| Rok vydání: |
2011 |
| Předmět: |
|
| Zdroj: |
Acta Anaesthesiologica Scandinavica. 55:486-494 |
| ISSN: |
0001-5172 |
| DOI: |
10.1111/j.1399-6576.2010.02390.x |
| Popis: |
BACKGROUND: Remifentanil labour analgesia is superior to nitrous oxide but less potent than epidural analgesia. The short onset and offset times of effect suggest that the timing of the bolus in the contraction cycle could have importance. We hypothesised that administering a remifentanil bolus during contraction pause would improve analgesia in early labour. METHODS: With permission from the ethical committee and the National Authority of Medicines, 50 parturients with uncomplicated singleton pregnancies and informed consent participated in a double blind cross-over study. Intravenous doses of 0.4 μg/kg remifentanil with 1-min infusion times were used during two study periods lasting six to eight contractions. Remifentanil and saline syringes were attached to two patient-controlled devices, one of which administered the bolus immediately after a trigger and the other targeted to start 140 s before the next contraction. The parturients assessed contraction pain, pain relief, sedation and nausea. Oxygen saturation (SaO(2)) pulse and blood pressure were recorded. SaO(2) |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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