Clindamycin-Induced Rhabdomyolysis in the Setting of Mitochondrial Myopathy

Autor:	Jack Xu, Thomas Nahass, Jessica Kunadia, Isao Iwata, Vivek Bose, Jonathan Lowenthal
Rok vydání:	2019
Předmět:	Host mitochondria business.industry Mechanical Engineering Metals and Alloys Clindamycin Pharmacology Mitochondrion medicine.disease Mitochondrial myopathy Mechanics of Materials Medicine business Rhabdomyolysis medicine.drug
Zdroj:	Case Reports in Internal Medicine. 6:10
ISSN:	2332-7251 2332-7243
Popis:	We present a patient with mitochondrial myopathy who developed rhabdomyolysis following treatment with clindamycin. While clindamycin is not yet linked to drug-induced rhabdomyolysis in the literature, other drugs with mechanisms of action similar to clindamycin have been shown to damage human host mitochondria. Given this, we contend that clindamycin may also be capable of causing mitochondrial injury, and that while in otherwise healthy patients it may not produce any negative clinical outcome, it can precipitate rhabdomyolysis in certain patients whose mitochondria are already vulnerable.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::42e2521ab3c7aeac65ad6d76e5a4bb4e https://doi.org/10.5430/crim.v6n3p10 Zobrazit plný text záznamu