| Autor: |
Catherine F. Ruff, Fernanda Juarez Anaya, Samuel J. Dienel, Adiya Rakymzhan, Alain Altamirano-Espinoza, Jay Couey, Alan M. Watson, Kenneth N. Fish, Bryan M. Hooks, Maria E. Rubio, Aihua Su, Sarah E. Ross, Alberto L. Vazquez |
| Rok vydání: |
2022 |
| DOI: |
10.1101/2022.10.11.511811 |
| Popis: |
Neuronal activity evokes a vascular response that is essential to sustain brain function. We show that neurovascular coupling (NVC) is mediated by long-range projecting GABAergic neurons that express Tacr1. Whisker stimulation elicited Tacr1 neuron activity in the barrel cortex through feed-forward excitatory pathways. Optogenetic activation of Tacr1 neurons elicited vasodilation, whereas inhibition significantly reduced whisker-evoked hemodynamic responses. Moreover, vasodilation was preceded by capillary pericyte activity, demonstrating a mechanism for NVC. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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