P6184Association of coronary plaque characteristics and the translesional gradient by FFRct in asymptomatic patients with newly diagnosed type-2 diabetes mellitus

Autor:	M Mrgan, B L Norgaard, D Dey, J B Gram, M H Olsen, N P R Sand
Rok vydání:	2019
Předmět:	medicine.medical_specialty business.industry Type 2 Diabetes Mellitus Newly diagnosed Chest pain medicine.disease Asymptomatic Blood pressure Coronary plaque Internal medicine Diabetes mellitus Cardiology Medicine medicine.symptom Cardiology and Cardiovascular Medicine business Calcification
Zdroj:	European Heart Journal. 40
ISSN:	1522-9645 0195-668X
DOI:	10.1093/eurheartj/ehz746.0790
Popis:	Background Coronary CT angiography (CCTA) derived fractional flow reserve (FFRct) is increasingly for decision-making in patients with stable chest pain. The relation between vessel specific plaque characteristics and the translesional gradient by FFRct in patients with type-2 diabetes mellitus (T2DM) is not fully explored. Purpose To examine the association between vessel specific plaque characteristics as determined by CCTA and the translesional gradient as assessed by FFRct in asymptomatic patients with newly diagnosed T2DM. Methods Total plaque volume and the volumes of calcified plaque (CP), low-density noncalcified plaque (LD-NCP) and non-LD-NCP were assessed on a per-vessel basis by quantitative plaque analysis using Autoplaque. Irregularities of the vessel wall giving a vessel-specific total plaque volume 1.1. Spotty calcification was defined as calcifications comprising 1.8 mm in diameter was registered. The translesional gradient, defined as the difference of FFRct-values immediately proximal and distal to lesion, was calculated in most severe lesion per-vessel. Lesions were categorized according to a ΔFFRct threshold of 0.06. Plaque analysis and comparison to ΔFFRct were performed by staff blinded to patient data. Results A total of 76 patients; age, mean (SD): 56 (11) years; males, n (%): 49 (65), with newly diagnosed (0.05. The vessel-specific CP volume, median (IQR), was higher in vessels with ΔFFRct ≥0.06 vs. ΔFFRct Conclusion In asymptomatic patients with newly diagnosed and well-controlled T2DM, the occurrence of high-risk coronary plaque features was frequently observed. The applied translesional gradient by FFRct was not predictive of adverse coronary plaque characteristics. Acknowledgement/Funding The Danish Diabetes Academy supported by the Novo Nordisk Foundation; University of Southern DenmarkCenter Southwest, Denmark
Databáze:	OpenAIRE
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