Reaction gas chromatography of alkyl halogenides. Optimization of the conversion into alkyl azides
Autor: | Liudmila Kartsova, B. V. Stolyarov, I. M. Balakin |
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Rok vydání: | 1978 |
Předmět: | |
Zdroj: | Chromatographia. 11:720-724 |
ISSN: | 1612-1112 0009-5893 |
Popis: | The central orthogonal composite design methodology is employed to find optimum conditions for the conversion of alkyl halogenides into alkyl azides in a chromatographic system. In spite of the difference in the chemical structure of the starting alkyl halogenides, we have found that there is a similarity in the effect of various factors on the conversion process of alkyl halogenides into the corresponding azides. Conditions have been established which provide 100% conversion of n-butyland isopropyl iodide. Computation of the response functions by the corresponding regression equations permitted us to define a region of optimum conditions common for the primary and secondary propyl- and n-butyl iodides and bromides, as well as for n-pentyl iodide providing for a conversion at least 90–95%. Differences in the relative retention times of the alkyl halogenides and the corresponding azides are sufficient to carry out identification by the peak shift method. |
Databáze: | OpenAIRE |
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