Reaction gas chromatography of alkyl halogenides. Optimization of the conversion into alkyl azides

Autor:	Liudmila Kartsova, B. V. Stolyarov, I. M. Balakin
Rok vydání:	1978
Předmět:	chemistry.chemical_classification Chemistry Chemical structure Peak shift Organic Chemistry Clinical Biochemistry Inorganic chemistry Iodide Biochemistry Isopropyl iodide Analytical Chemistry chemistry.chemical_compound Organic chemistry Gas chromatography Alkyl
Zdroj:	Chromatographia. 11:720-724
ISSN:	1612-1112 0009-5893
Popis:	The central orthogonal composite design methodology is employed to find optimum conditions for the conversion of alkyl halogenides into alkyl azides in a chromatographic system. In spite of the difference in the chemical structure of the starting alkyl halogenides, we have found that there is a similarity in the effect of various factors on the conversion process of alkyl halogenides into the corresponding azides. Conditions have been established which provide 100% conversion of n-butyland isopropyl iodide. Computation of the response functions by the corresponding regression equations permitted us to define a region of optimum conditions common for the primary and secondary propyl- and n-butyl iodides and bromides, as well as for n-pentyl iodide providing for a conversion at least 90–95%. Differences in the relative retention times of the alkyl halogenides and the corresponding azides are sufficient to carry out identification by the peak shift method.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::42d93f426138ff7b3c90f7ebf6487b28 https://doi.org/10.1007/bf02269107 Zobrazit plný text záznamu Full text from SpringerLink