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Objective: This study aims to investigate the effect of Chinese herbs treatment of Kidney-strengthening therapy, Spleen-invigorating therapy and Liver-regulating therapy on monoamine neurotransmitters in ovariectomized female rats. Methods: 54 female rats were divided into six groups by random: control group, sham operation group, model group, Spleen-invigorating group, Kidney-strengthening group and Liver-regulating group. Each group contained 9 rats. The organ index of hypothalamic pituitary and uterus and serum serotonin (5-HT) and dopamine (DA) test was compared after treating with 8 weeks. Results: The organ index of hypothalamic pituitary and uterus in model group dcreased with significant difference (p 0.05) comparing with model group. On the effect of serum serotonin and dopamine, model group showed significantly decline in the content of serum serotonin comparing to control group (P 0.05) in all groups treated with Chinese herb formulae. Conclusion: Different Chinese herbs treatment of Spleen-invigorating therapy, Kidney-strengthening therapy and Liver-regulating therapy may improve monoamine neurotransmitters in ovariectomized female rats by different targets. Spleen-invigorating group was more effected in improving monoamine neurotransmitters than other two groups. |
