Effect of treatment with simvastatin on bone microarchitecture of the femoral head in an osteoporosis animal model
Autor: | Ana Paula Macedo, Lucas Oliveira Monteiro, Marina Ribeiro Paulini, Roberta Carminati Shimano, Miliane Gonçalves Gonzaga, João Paulo Mardegan Issa, Fellipe Augusto Tocchini de Figueiredo, Antonio Carlos Shimano, Gabriela Rezende Yanagihara, Junia Ramos |
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Rok vydání: | 2016 |
Předmět: |
medicine.medical_specialty
Histology Osteoporosis 030209 endocrinology & metabolism Metabolic bone disease 03 medical and health sciences Femoral head 0302 clinical medicine Internal medicine polycyclic compounds medicine Ingestion Femur Instrumentation business.industry Sham surgery medicine.disease Medical Laboratory Technology Endocrinology medicine.anatomical_structure Simvastatin 030220 oncology & carcinogenesis Ovariectomized rat Anatomy business medicine.drug |
Zdroj: | Microscopy Research and Technique. 79:684-690 |
ISSN: | 1059-910X |
Popis: | The objective of this study was to evaluate the microarchitecture and trabecular bone strength at the distal region of the femur, and its biomechanical properties with simvastatin administration with two different doses in ovariectomized (OVX) rats. Ninety rats were divided into six groups to evaluate treatment with the simvastatin drug (n = 15): SH (Sham surgery), SH-5 (5 mg simvastatin), SH-20 (20 mg simvastatin), OVX, OVX-5, and OVX-20. Euthanasia was performed at three different times, five animals per period: 7, 14, and 28 days. The effectiveness of the treatments was evaluated by mechanical testing and histomorphometric analysis of the femurs. The results of analysis by the linear model of mixed effects showed 20 mg of simvastatin results in increased trabecular bone after 14 days (P = 0.039) of ingestion in ovariectomized animals. However, ingestion of 5 mg of simvastatin is able to sensitize the trabecular bone only at 28 days (P = 0.005) of ingestion. In the mechanical tests stiffness improves within 28 days (P = 0.003). Regarding maximum strength, no statistical differences were observed. According to these results, it can be concluded that for a decrease in oral intake, longer treatment times are required. Microsc. Res. Tech. 79:684-690, 2016. © 2016 Wiley Periodicals, Inc. |
Databáze: | OpenAIRE |
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