Atherosclerotic plaque metabolism in high cardiovascular risk subjects – A subclinical atherosclerosis imaging study with 18F-NaF PET-CT
| Autor: | Manuel Oliveira-Santos, Andreia Gomes, Rodolfo Silva, João L. M. P. de Lima, Maria João Ferreira, Mariano Pego, Lino Gonçalves, Antero J. Abrunhosa, Paulo Donato, Miguel Castelo-Branco, Nuno Chichorro |
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| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
PET-CT Aorta medicine.diagnostic_test business.industry Standardized uptake value 030204 cardiovascular system & hematology medicine.disease 030218 nuclear medicine & medical imaging Coronary Calcium Score Coronary arteries Lesion 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Positron emission tomography Internal medicine medicine.artery Cardiology Medicine Radiology medicine.symptom Cardiology and Cardiovascular Medicine business Calcification |
| Zdroj: | Atherosclerosis. 260:41-46 |
| ISSN: | 0021-9150 |
| Popis: | Background and aims Atherosclerotic plaque molecular imaging with 18 F-sodium fluoride (NaF) in positron emission tomography with computed tomography (PET-CT) provides potential discrimination between active unstable microcalcification and established dormant calcification. We aimed to study 18 F-NaF atherosclerotic plaque uptake in high cardiovascular (CV) risk participants and its associations with CV risk factors, coronary calcium score and thoracic fat volume. Methods High CV risk hypertensive individuals from a single centre were prospectively scanned with 18 F-NaF-PET-CT in the coronary, aortic and carotideal arteries. Atherosclerotic plaque 18 F-NaF uptake was expressed as Corrected Uptake per Lesion (CUL): maximum standard uptake value in each vascular territory subtracted by mean blood pool activity. Results Mean age was 64 years, 56% male and 96% Caucasian (n = 25). Ninety six per cent of the subjects showed 18 F-NaF uptake in the aorta (CUL 0.9 ± 0.3), 40% in the carotid arteries (median CUL 0.0, IQR 0.0–0.7) and 64% in the coronary arteries (0.4, IQR 0.0–0.6). Individuals with ≥ five risk factors (60%) had increased overall 18 F-NaF uptake (1.1 ± 0.3 vs . 0.7 ± 0.3, p p = 0.01). There was no correlation between 18 F-NaF uptake in the coronary arteries and calcium score ( p = 0.87). Thoracic fat was moderately correlated with overall CUL (r = 0.41, p = 0.04). Conclusions In a high CV risk group, 18 F-NaF atherosclerotic plaque uptake was related to the burden of CV risk factors and thoracic fat volume, but there was no association between coronary uptake and calcium score. |
| Databáze: | OpenAIRE |
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