Application of a modified central composite design to optimize the capillary electrochromatographic separation of related S-oxidation compounds

Autor:	Christopher M. Riley, John H. Miyawa, Mark Alasandro
Rok vydání:	1997
Předmět:	Capillary electrochromatography Chromatography Central composite design Chemistry Hydrochloride Capillary action Organic Chemistry General Medicine Biochemistry Analytical Chemistry chemistry.chemical_compound Electrochromatography Volume fraction Acetonitrile Antibacterial agent
Zdroj:	Journal of Chromatography A. 769:145-153
ISSN:	0021-9673
DOI:	10.1016/s0021-9673(97)00081-2
Popis:	Capillary electrochromatography was employed to separate the antibacterial 3-[4-(methylsulfinyl) phenyl]-5S-acetamidomethyl-2-oxazolidinone from its related S-oxidation products. The separation was optimized by a systematic search for the optimal separation conditions employing a modified central composite design. The variables examined in the optimization were in terms of applied potential, volume fraction of acetonitrile and buffer (Tris hydrochloride) concentration. A response surface mapping for selected variables at an applied potential of 25 kV was also performed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::42caddd1afc9f7146983a692d27e55f5 https://doi.org/10.1016/s0021-9673(97)00081-2 Zobrazit plný text záznamu Full Text from ScienceDirect