Summary of a Symposium on Natriuretic and Digitalis-Like Factors

Autor:	Harvey C. Gonick, Vardaman M. Buckalew
Rok vydání:	1998
Předmět:	medicine.medical_specialty biology Digitalis-like factors Physiology Digitalis Endogeny General Medicine Pharmacology biology.organism_classification Bufodienolides Ouabain Endocrinology Natriuretic Factors Internal medicine Internal Medicine medicine medicine.drug
Zdroj:	Clinical and Experimental Hypertension. 20:481-488
ISSN:	1525-6006 1064-1963
DOI:	10.3109/10641969809053226
Popis:	An international symposium on natriuretic and digitalis-like factors was convened for the first time since 1992. Topics discussed included structures and biosynthesis of endogenous digitalis-like factors (EDLF), biologic activities, physiology function and role of EDLF in hypertension, and novel natriuretic factors. Progress was reported in determining the exact structure of an isomer of ouabain isolated from bovine hypothalamus. Evidence was presented supporting the existence of a second mammalian EDLF that resembles steroids found in toads (bufodienolides). Support for endogenous synthesis of mammalian EDLF was also presented. Mammalian EDLF were reported to have effects which are different from those possessed by digitalis like steroids derived from plants. New evidence was presented implicating EDLF in various forms of hypertension in humans and animal models. Finally, several unique natriuretic factors that do not inhibit Na, K ATPase and that appear to play a role in mammalian volume regulation were discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::42c4bd95cc6140ababb7fa7787c86fa9 https://doi.org/10.3109/10641969809053226 Zobrazit plný text záznamu