Suppressive Effect of Dextran on Platelet Adhesiveness

Autor:	B Robertson, Inga Marie Nilsson, Jan‐Erik Niléhn, Stig Cronberg
Rok vydání:	1966
Předmět:	chemistry.chemical_compound Dextran chemistry business.industry Platelet adhesiveness Medicine Hematology Pharmacology business
Zdroj:	Thrombosis and Haemostasis. 16:384-394
ISSN:	2567-689X 0340-6245
DOI:	10.1055/s-0038-1655597
Popis:	Summary43 normal volunteers, 3 patients with thrombophlebitis, and 1 patient with a high platelet adhesiveness and a history of thrombophlebitis have received dextran and its action on the mechanism of haemostasis has been studied. Platelet adhesiveness has been investigated by a slight modification of Hellem’s methods for whole blood and plasma. Dextran with a mean molecular weight of 70,000 produced a markedly lowered platelet adhesiveness together with a moderate prolongation of the Ivy bleeding time. Factor VIII was decreased by about 50% and factor V, factor IX and fibrinogen were decreased slightly more than could be expected from haemodilution alone. No fibrinolysis occurred. Dextran of lower molecular size was less potent. The possible use of dextrans as a thrombosis prophylactic agent is discussed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::42bd2eae8c327d1d19134b10de58239a https://doi.org/10.1055/s-0038-1655597 Zobrazit plný text záznamu