Tranexamic Acid for Prevention of Postpartum Hemorrhage after Vaginal Delivery
| Autor: | Ashraf Hamdy Mohamed, Esmail Talaat El-Garhy, Mohamed Awad Allah Hamed, Ibrahim Abu Elmagd, Ashraf El-Shahat |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
030219 obstetrics & reproductive medicine
Vaginal delivery business.industry Placebo-controlled study Placebo Confidence interval 03 medical and health sciences 0302 clinical medicine Blood loss Relative risk Anesthesia medicine 030212 general & internal medicine Adverse effect business Tranexamic acid medicine.drug |
| Zdroj: | The Egyptian Journal of Hospital Medicine. 73:6157-6164 |
| ISSN: | 2090-7125 |
| DOI: | 10.21608/ejhm.2018.12737 |
| Popis: | Objective: To assess the efficacy of tranexamic acid in reduction of blood loss and pervention of postpartum hemorrhage after vaginal delivary. Methods: This is a multicentric prospective randomized double blind placebo controlled trial. 200 pregnant women were randomized to receive either 60 mg/kg of tranexamic acid (TA) (n=100) or placebo (n=100) intravenously in the second stage of labour. Postpartum blood loss was collected and measured accurately from placental delivery to 2 hours postpartum and adverse effects of were observed. Results: The mean estimated postpartum blood loss was significantly lower in women treated with tranexamic acid compared to women in the placebo group ( 442.50 ± 128.55 versus 555.75 ± 191.88, respectively; p < 0.001), and the proportion of women in the tranexamic acid group who had an estimated blood loss ≥ 500 mL was significantly lower than in the placebo group( 3 [3 %] versus 9 [9%],relative risk [RR]=0.30; 97% confidence interval [CI] 0.11 to 0.78;P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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