| Popis: |
This review deals with the synthesis and chemical functionalization of sulfur- and nitrogen-containing [5,5]-fused ring systems with one nitrogen atom in the bridgehead position and a fixed sulfur atom. With up to three additional nitrogen atoms, there are 21 possible ring structures. Of these, only nine are found reported in the literature in more than an anecdotal manner. These scaffolds play an important role in the design and synthesis of biologically active molecules, and the chemistry of these compounds is rich and varied. Their use in medicinal chemistry has grown exponentially in the past few years, especially in the context of molecular diversity. These scaffolds are also bioisosters of indolizines, imidazopyridazines, and their derivatives. |
