NEW APPROACHES TO COMPLEX CORRECTION HYPOTHYROIDISM AND ITS RELATED COMPLICATIONS
| Autor: | A. V. Spiridonov, N. G. Malova, L. A. Sirotenko, L. Yu. Sergiyenko, K. S. Anikeyeva, I. V. Komarova |
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| Rok vydání: | 2016 |
| Předmět: |
endocrine system
medicine.medical_specialty endocrine system diseases business.industry Endocrinology Diabetes and Metabolism Osteoporosis Thyroid Lumbar vertebrae medicine.disease Pathology and Forensic Medicine Endocrinology medicine.anatomical_structure Internal medicine Concomitant medicine Endocrine system business |
| Zdroj: | Problems of Endocrine Pathology. 58:71-81 |
| ISSN: | 2518-1432 2227-4782 |
| DOI: | 10.21856/j-pep.2016.4.10 |
| Popis: | It was studied the specific multipotent performance synthetic compounds with a number of tryazolopyrymides 7-(3-hydroxyphenyl)-6-carbetoxy-5-methyl-4,7-dihydro[1,2,4]triazolo [1,5-a]pyrymidyn (NE-99) in thyroid and skeletal system of Wistar rats with experimental hypothyroidism. It was proved the positive effect of the compound YV-99 on the structure and functions of the thyroid gland and found it osteoprotect effect on bone lumbar vertebrae experimental animals. The obtained data allow us to consider this compound as a comprehensive tool to correct hypothyroidism thyroid and endocrine concomitant osteoporosis. |
| Databáze: | OpenAIRE |
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