| Popis: |
In our ongoing investigation of the bioactive constituents from plants, two new lignans, magnolignan A-2-O-β-D-glucopyranoside and strebluslignanol were isolated from heartwood of Streblus asper, along with three known lignans, magnolignan A, magnolol, and magnaldehyde D. 1D and 2D NMR experiments, including COSY, HMQC, and HMBC, and other spectroscopic methods, including UV, IR, and MS were used for the determination of the structures and NMR assignments. Primary bioassays showed that magnolignan A-2-O-β-D-glucopyranoside and strebluslignanol have medium cytotoxic activity against HEp-2 and HepG2 cells, with IC50 of 13.3 µM, 46.4 µM and 10.1 µM, 21.7 µM, respectively. Copyright © 2008 John Wiley & Sons, Ltd. |
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