Increased α CGRP potency and CGRP-receptor antagonist affinity in isolated hypoxic porcine intramyocardial arteries

Autor:	Karen Eskesen, Philip Hasbak, Lars Edvinsson, Søren Schifter
Rok vydání:	2005
Předmět:	Pharmacology medicine.medical_specialty medicine.drug_class Antagonist Vasodilation Calcitonin gene-related peptide Biology Receptor antagonist Adenosine Adrenomedullin Endocrinology Internal medicine medicine Calcitonin receptor Receptor medicine.drug
Zdroj:	British Journal of Pharmacology. 145:646-655
ISSN:	0007-1188
Popis:	1. This study describes the effects of hypoxia on relaxing responses and cAMP production induced by the known vasodilator peptides: alphaCGRP, amylin (AMY) and adrenomedullin (AM) on isolated pig coronary arteries in vitro. 2. Hypoxic incubation increased the vasorelaxant effect of alphaCGRP (four-fold; P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::429b2702ffe293fefe334db8f641759c https://doi.org/10.1038/sj.bjp.0706232 Zobrazit plný text záznamu Plný text ve formátu PDF