An efficient route to highly functionalized benzene derivatives by rhodium-catalyzed dimerization of diynes
| Autor: | Fen Xu, Yan-Yu Meng, Qian-Nan Mu, Yuan-Yuan Song, Wei-Fen Kang, Hui Cui |
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| Rok vydání: | 2018 |
| Předmět: |
chemistry.chemical_classification
010405 organic chemistry General Chemical Engineering Intermolecular force Alkyne chemistry.chemical_element General Chemistry 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry Toluene Industrial and Manufacturing Engineering Cycloaddition 0104 chemical sciences Catalysis Rhodium chemistry.chemical_compound chemistry Materials Chemistry Molecule Selectivity |
| Zdroj: | Chemical Papers. 72:1363-1368 |
| ISSN: | 1336-9075 2585-7290 |
| DOI: | 10.1007/s11696-018-0391-0 |
| Popis: | An intermolecular efficient dimerization of diynes via Rh-catalyzed cycloaddition is presented. This protocol allows for the expedient synthesis of structurally diverse benzene derivatives, which retain an alkyne unit for post-functionalization to realize molecules with potential medicinal value and extended molecular complexity. The transformation is carried out in toluene and employs Rh(COD)2OTf3 as the metal source. Diversely decorated diynes tethered by nitrogen atom and ester were compatible with these conditions and furnished substituted benzenes with excellent selectivity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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