Role of the Serotonergic System in Suppression of Visceral Pain Induced in Mice by Preliminary Microwave Irradiation of an Acupuncture Point

Autor:	Ye. V. Gura, Ye. V. Bagatskaya
Rok vydání:	2015
Předmět:	Pain syndrome Physiology business.industry General Neuroscience Visceral pain Pharmacology Serotonergic Blockade Acupuncture point Anesthesia Microwave irradiation Medicine Serotonin Irradiation medicine.symptom business
Zdroj:	Neurophysiology. 47:238-243
ISSN:	1573-9007 0090-2977
DOI:	10.1007/s11062-015-9527-9
Popis:	In experiments on male albino mice, we examined the role of the serotonergic cerebral system in analgesia induced by microwave irradiation of the acupuncture point (AP) E-36. Two modes of irradiation were used: broadband (30–300 GHz) radiation with low-frequency (0.1–100 Hz) amplitude modulation and fixed-frequency (61 ± 4 GHz) radiation. Irradiation of the AP preceded induction of visceral pain by i.p. injections of acetic acid. A blocker of serotonin (ST) synthesis, DL para-chlorophenylalanine (PCPA, 300 mg/kg), introduced 72 h before injection of acetic acid, provided significant prolongation of manifestations of the pain behavioral reaction (PBR) by 41.6 and 66.7%, respectively, as compared with the duration of this reaction in mice subjected to irradiation of the AP in the above modes but with no PCPA injection (P < 0.05 in both cases). Intensification of the PBR against the background of blockade of ST synthesis shows that the respective cerebral system is significantly involved in analgesia induced by preliminary (preceding the induction of the pain syndrome) microwave irradiation of the AP E-36.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::427253f6980a734db420a4c07bd1f8aa https://doi.org/10.1007/s11062-015-9527-9 Zobrazit plný text záznamu Plný text ve formátu PDF