Benefits of Glucose-Insulin-Potassium before Mitral Valve Replacement
| Autor: | Yavuz Beşoğul, Ömer Çolak, Bülent Tünerir, Tuğrul Kural, Serap Işiksoy, Recep Aslan |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Pulmonary and Respiratory Medicine
Inotrope medicine.medical_specialty Cardiac output Glycogen business.industry medicine.medical_treatment Mitral valve replacement General Medicine chemistry.chemical_compound medicine.anatomical_structure chemistry Internal medicine medicine Vascular resistance Cardiology Surgery Cardiology and Cardiovascular Medicine Pulmonary wedge pressure business Saline Papillary muscle |
| Zdroj: | Asian Cardiovascular and Thoracic Annals. 6:273-278 |
| ISSN: | 1816-5370 0218-4923 |
| DOI: | 10.1177/021849239800600409 |
| Popis: | Of 30 consecutive patients undergoing mitral valve replacement, 15 were randomly assigned to receive pretreatment with glucose-insulin-potassium, while the other 15 received the same volume of normal saline. The characteristics of both groups were similar and all patients were in New York Heart Association functional class III or IV. Papillary muscle samples were obtained at the time of surgery and analyzed for glycogen both biochemically and histochemically. The clinical course was monitored closely during the first 24 hours after surgery. The treated patients had significantly higher glycogen levels (mean, 43 ± 13.54 μmol·g−1) in their heart muscle samples compared to the controls (mean, 22 ± 10.39 μmol·g−1). The treated patients required less pharmacological inotropic support and they had fewer ventricular arrhythmias and more favorable cardiac output and systemic vascular resistance. However, there was no difference in postoperative pulmonary capillary wedge pressure or mortality between the 2 groups. It was concluded that pretreatment with glucose-insulin-potassium had a significant myocardial protective effect in patients in advanced functional class undergoing mitral valve replacement. |
| Databáze: | OpenAIRE |
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