ChemInform Abstract: Synthesis of the Cardiotonic Bemarinone, 5,6-Dimethoxy-4-methyl-2(1H)- quinazolinone, Utilizing a Directed Metalation Approach

Autor:	Barton Donald L, Stephen M. Stefanick, Arthur C. Fabian, Gregory C. Lindabery, Charles Francis Kasulanis, Stephen Currey, Sergio Cesco-Cancian, Margaret M. Lam, Seymour D. Levine, Conley Richard A
Rok vydání:	2010
Předmět:	chemistry.chemical_compound chemistry Metalation Electrophile Organic chemistry Bemarinone General Medicine Combinatorial chemistry Quinazolinone
Zdroj:	ChemInform. 26
ISSN:	0931-7597
Popis:	Several methods for the synthesis of bemarinone, 5,6-dimethoxy-4-methyl-2(1H)-quinazolinone, were explored with the most successful being a directed metalation route. Details of the lithiation and the subsequent reaction with electrophiles of 3′,4′-dimethoxy-2,2-dimethylpropioanilide and other derivatives of 3,4-dimethoxyaniline are given.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::426c802e0d94f7c4f3395926030a8e74 https://doi.org/10.1002/chin.199545186 Zobrazit plný text záznamu Plný text