Varicella in Immunocompetent Children in the First Two Years of Life: Role of Treatment with Oral Acyclovir

Autor: G. Ghirardini, Patrick J. Antonelli, S. Catania, A. Vierucci, D. Pavesio, A. Rasore, B. Loizzo, F. Marcucci, G. Caramia, U. De Santis, V. Carnelli, M. Ceccarelli, L. Titone, Roberto Manfredi, Francesco Chiodo
Rok vydání: 1995
Předmět:
Zdroj: Journal of Chemotherapy. 7:62-66
ISSN: 1973-9478
1120-009X
Popis: An open multicenter study has been carried out to evaluate efficacy and tolerability of oral acyclovir in the treatment of varicella in immunocompetent patients in the first two years of life. Fifty-three children aged 3-24 months received acyclovir at 80 mg/kg/day in four divided doses for 4 to 6 days; 24 of them were treated in the first 24 hours following disease onset, while the remaining 24 patients were enrolled within 48 hours. The assessment of evolution of disease signs and symptoms showed a rapid resolution of fever, itching and other constitutional symptoms, with interruption of vesicle formation and acceleration of cutaneous healing processes. No statistically significant differences have been demonstrated as to disease progression between patients treated in the first 24 hours, when compared with subjects receiving acyclovir in the following 24 hours. Acyclovir confirmed its excellent clinical and laboratory safety profile. By acting favorably on both the duration and severity of disease signs and symptoms, acyclovir treatment should be recommended in young children and infants with varicella, since a higher incidence of severe and complicated disease has been observed in these patient groups
Databáze: OpenAIRE
Externí odkaz: