Highly stereoselective preparation of (3R,4S)-3,4-chromanediol by deracemization of (±)-3-hydroxy-4-chromanone by Trichosporon cutaneum

Autor:	Gelson José Andrade da Conceição, Paulo J. S. Moran, Inês Lunardi, J. Augusto R. Rodrigues
Rok vydání:	2005
Předmět:	Inorganic Chemistry Chemistry Stereochemistry Organic Chemistry Trichosporon cutaneum Organic chemistry Stereoselectivity Physical and Theoretical Chemistry Enantiomer 4-chromanone Catalysis Yeast
Zdroj:	Tetrahedron: Asymmetry. 16:2515-2519
ISSN:	0957-4166
DOI:	10.1016/j.tetasy.2005.06.020
Popis:	Deracemization of (±)-3-hydroxy-4-chromanone 2 through stereoselective bioreduction to the corresponding (3R,4S)-3,4-chromanediol 3, with good to excellent enantiomeric excesses (up to 99%), mediated by resting cells of the yeast Trichosporon cutaneum CCT 1903, is reported. In addition, 3-hydroxychromone (7) was obtained as a secondary product.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::42500c5e1b43708bd99f678e0080a4bf https://doi.org/10.1016/j.tetasy.2005.06.020 Zobrazit plný text záznamu Full Text from ScienceDirect