Structural characterization, antibacterial activity and NorA efflux pump inhibition of flavonoid fisetinidol
| Autor: | Horlando C. da Silva, Gilvandete M. P. Santiago, Henrique Douglas Melo Coutinho, Humberto Medeiros Barreto, Thiago Sampaio de Freitas, Mauro Macedo de Oliveira, Igor Kleber Campos Lima, Alexandre Magno Rodrigues Teixeira, Antonio Linkoln Alves Borges Leal, Carlos Emídio Sampaio Nogueira, Hélcio Silva dos Santos |
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| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
chemistry.chemical_classification medicine.drug_class Chemistry Antibiotics Flavonoid food and beverages Plant Science Pharmacology 01 natural sciences 0104 chemical sciences 010404 medicinal & biomolecular chemistry Antibiotic resistance Polyphenol medicine Antispasmodic Efflux Antibacterial activity Norfloxacin 010606 plant biology & botany medicine.drug |
| Zdroj: | South African Journal of Botany. 132:140-145 |
| ISSN: | 0254-6299 |
| Popis: | Flavonoids belong to the extensive group of polyphenols and have several biological activities such as anti-inflammatory, anti-ulcer, anticancer, antiviral, antibacterial, and antispasmodic. These compounds can thus be explored as a tool against multidrug resistant bacteria, as nosocomial infections now constitute a major public health problem worldwide. We have carried out a structural characterization by nuclear magnetic resonance and FT-IR of fisetinidol, a flavonoid isolated from B. pentandra stems. In addition, this flavonoid was tested for antibacterial and modulatory activities, as well as inhibition of the NorA efflux pump. Fisetinidol has no intrinsic antibacterial activity. However, there is synergism in association with norfloxacin, with a two-fold decrease in MIC. When compared to chlorpromazine, a standard efflux pump inhibitor, a two-fold decrease in MIC was also verified when used against S. aureus SA-1199B, which over expresses the NorA gene encoding the NorA efflux protein. As such, it could become an alternative source to reverse the bacterial resistance if administered in association with antibiotics. |
| Databáze: | OpenAIRE |
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