Hormonal and Behavioral Characteristics of Prenatally Stressed Female Rats in an Experimental Model of Depression
| Autor: | V. K. Akulova, V. V. Rakitskaya, Svetlana Pivina, V. I. Mironova, Natalia Ordyan |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Vasopressin Pregnancy business.industry General Neuroscience Physiology Learned helplessness medicine.disease Open field 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine chemistry Prenatal stress Corticosterone Medicine business 030217 neurology & neurosurgery Depression (differential diagnoses) Behavioural despair test |
| Zdroj: | Neuroscience and Behavioral Physiology. 49:573-579 |
| ISSN: | 1573-899X 0097-0549 |
| DOI: | 10.1007/s11055-019-00772-6 |
| Popis: | Changes in behavior and hypothalamo-hypophyseal-adrenal system (HHAC) activity were studied in adult prenatally stressed female rats in an experimental model of depression, i.e., learned helplessness. Females born to intact mothers were found not to form depression-like behavior, as evidenced by the absence of changes in HHAC activity, despite reductions in locomotor activity in the open field and increases in the duration of immobility in the forced swimming test. At the same time, females born to mothers stressed during the last weeks of pregnancy showed changes in behavior and HHAC activity analogous to those found in our previous studies of these animals in the stress-restress paradigm. These results lead to the conclusion that prenatal stress modifies animals’ sensitivity to intense stressors. This is apparent in the specific pattern of HHAC activity after stressing, independently of the type of stress. |
| Databáze: | OpenAIRE |
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