Decreased Oral Bioavailability of Lansoprazole in Healthy Volunteers when Given with a Standardised Breakfast

Autor:	Bertil Olofsson, Robert Bergstrand, Margaretha Grind, Gunnar Nyberg
Rok vydání:	1995
Předmět:	business.industry digestive oral and skin physiology Lansoprazole Cmax General Medicine Pharmacology Crossover study Bioavailability Single oral dose Peak plasma Pharmacotherapy Healthy volunteers medicine Pharmacology (medical) business medicine.drug
Zdroj:	Clinical Drug Investigation. 9:67-71
ISSN:	1173-2563
DOI:	10.2165/00044011-199509020-00002
Popis:	12 healthy male volunteers participated in this open, randomised, crossover study. On 2 study days at least 6 days apart the volunteers were given a single oral dose of lansoprazole 30mg with or without a standardised breakfast. When lansoprazole was concomitantly given with breakfast, the peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) were decreased by approximately 50% for each of the two parameters. The time to reach Cmax (tmax) was doubled when lansoprazole was coadministered with breakfast. In conclusion, lansoprazole should not be taken concomitantly with food.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::4233b7542dba68851ba5b58e95a89385 https://doi.org/10.2165/00044011-199509020-00002 Zobrazit plný text záznamu Full text from SpringerLink