Synthesis of in vivo potent antimalarial 1,2,4-trioxanes

Autor:	Subhash Chandra, Chandan Singh, Gunjan Saxena, Dharmendra Misra
Rok vydání:	1992
Předmět:	biology Chemistry Organic Chemistry Clinical Biochemistry Condensation Pharmaceutical Science biology.organism_classification Biochemistry In vivo Yield (chemistry) Drug Discovery Molecular Medicine Photooxygenation Organic chemistry Plasmodium berghei Molecular Biology
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 2:497-500
ISSN:	0960-894X
DOI:	10.1016/s0960-894x(00)80177-8
Popis:	β-Hydroxyhydroperoxides ( 5a–h ) derived from 3-aryl-2-butenol ( 6a–h ) by dye-sensitized photooxygenation undergo a facile acid-catalysed condensation with 2-adamantanone to yield 1,2,4-trioxanes ( 8a–h ). These trioxanes are stable at room temperature, can be stored in refrigerator for a year and are active against Plasmodium berghei in mice.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::42252ba0ba3f2c05ae7db3b7458ab92e https://doi.org/10.1016/s0960-894x(00)80177-8 Zobrazit plný text záznamu