Sulfobetaine zwitterionic inhibitors of squalene synthase

Autor:	Peide Gu, Thomas A. Spencer, Alfredo Castro, Ishaiahu Shechter, Reginald O. Cann, Thomas J. Onofrey, Guojian Jiang
Rok vydání:	1996
Předmět:	ATP synthase biology Chemistry Stereochemistry Organic Chemistry Clinical Biochemistry Pharmaceutical Science Reaction intermediate Biochemistry Squalene chemistry.chemical_compound Drug Discovery biology.protein Molecular Medicine Molecular Biology
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 6:2585-2588
ISSN:	0960-894X
DOI:	10.1016/0960-894x(96)00485-4
Popis:	Zwitterions such as farnesyl sulfobetaine 8 are a new type of inhibitor of squalene synthase that, while maintaining overall neutrality, mimic both the carbocationic and anionic moieties of presumed reaction intermediates. The most effective zwitterionic sulfobetaines discovered to date are aromatic derivatives 17 (IC 50 = 2 μM) and 20 (IC 50 = 5 μM).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::421e79d793ea4013eb79fa527db9c94d https://doi.org/10.1016/0960-894x(96)00485-4 Zobrazit plný text záznamu Full Text from ScienceDirect