| Popis: |
Several approaches to magnetic resonance (MR) measurements of tumor perfusion (i.e., the nutritive blood flux through tissues at the capillary level, alternatively termed tumor blood flow) and other properties of the tumor vasculature have been used in both preclinical and clinical studies. This chapter will first describe the principal approaches that have been used for measuring tumor perfusion and vascularity, including the data analysis methods used to extract quantitative information relating to the underlying tumor physiology. The remainder of the chapter will focus on dynamic contrast-enhanced MRI (DCE-MRI), which is currently the most widely used of these approaches. The methodological considerations for data acquisition, consensus approaches for data analysis, potential advances in DCE-MRI, and applications representative of how it is being used in drug development will be considered. |
