| Autor: |
A. Novara, Jean Chastre, Y. Domart, F. Blanchet, Gibert C, P. Montravers, Jean-Yves Fagon |
| Rok vydání: |
2015 |
| Předmět: |
|
| DOI: |
10.1159/000419705 |
| Popis: |
Activated neutrophils are directly involved in the parenchymal cell and connective tissue derangements characteristic of the adult respiratory distress syndrome (ARDS). Inflammatory cytokins, especially tumor necrosis factor alpha (TNFα) and interleukin-1 (IL-1) released from macrophages and lymphocytes enhance the inflammatory response of neutrophils. Pentoxifylline (PTX) has been shown to afford inhibitory effects on neutrophils and to counter the inflammatory cytokin-induced effects. Moreover, protective effects of PTX have been demonstrated on animal models of lung injury and experimental lung injury simulating ARDS. These results led to hope that PTX should be useful in blocking the mechanisms of alveolar capillary injury in patients with ARDS. This pilot study was designed to evaluate the effects of large doses of PTX on pulmonary gas exchange and pulmonary and systemic hemodynamics.Six consecutive patients with ARDS were included in this study. Hemodynamic measurements were performed using a pulmonary arterial catheter and an arterial catheter. PTX infusion was not begun unless steady state hemodynamic and gasometric measurements were ensured for the preceding 2 hours. PTX was then administered with an initial 1 mg/kg bolus over 15 minutes (min), followed by 1.5 mg/kg/hour constant infusion over 6 hours.PTX infusion induced a slight rise in heart rate that was already significant after 30 minutes of infusion (109 ± 4 at control to 112 ± 3 beats/min) (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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