Autor: S. M. Nasmetova, M. R. Shakirzyanova, A. M. Kerbalaeva, T. G. Gulyamova, Dilorom Ruzieva
Rok vydání: 2001
Předmět:
Zdroj: Biochemistry (Moscow). 66:979-981
ISSN: 0006-2979
DOI: 10.1023/a:1012313408062
Popis: The activities of nuclear enzymes involved in NAD+ metabolism in Saccharomyces cerevisiae strain 913a-1 and its mutant 110 previously selected as an NAD+ producer were investigated. The presence of extracellular nicotinamide increased the total NAD+ pool in the cells and increased [3H]nicotinic acid incorporation; however, NAD+ concentration in isolated nuclei decreased slightly. The stimulating effect of nicotinamide on intracellular synthesis of NAD+ correlated with increases in ADP-ribosyl transferase, NAD+-pyrophosphorylase, and NAD+ ase activities.
Databáze: OpenAIRE