Chronomodulation of Withdrawal Signs in Morphine-Dependent Rats

Autor:	H C Akunne, R L Williams, Karam F.A. Soliman, V K Nonavinakere
Rok vydání:	1997
Předmět:	Teeth chattering Morphine sulphate Physiology business.industry medicine.medical_treatment Physiology (medical) Anesthesia Naloxone medicine Morphine business Saline Ecology Evolution Behavior and Systematics medicine.drug
Zdroj:	Biological Rhythm Research. 28:410-416
ISSN:	1744-4179 0929-1016
DOI:	10.1076/brhm.28.4.410.13121
Popis:	Male Sprague-Dawley rats (200–250 g) were segregated into 12 groups (n =5). Six groups were injected with morphine sulphate (10,20,30,50 mg/kg,ip) on days 1, 2, 3 and 4 respectively. The specified dose of morphine was given in two divided doses daily at 1000 h (light) and 2200 h (dark) for four consecutive days. The remaining six groups received saline. On day 5, the rats from saline and morphine treated groups were injected with naloxone (50 mg/kg, ip) at 0600 h, 1000 h, 1400 h, 1800 h, 2200 h, or 0200 h to precipitate the withdrawal signs during the light and dark phases of the 24 h period. Withdrawal signs were monitored for the following 30 min. Diarrhea, tremor, teeth chattering and crying (vocalization) were exhibited exclusively by the morphine-dependent rats. Escape attempts and restless activity were observed mostly in morphine-dependent groups, except for a limited response by controls at 0200 h or 0600 h. The percentage response of other signs such as hunch-back posture, piloerection, stereotyp...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::420636e3520c898561f7d0be870e98fa https://doi.org/10.1076/brhm.28.4.410.13121 Zobrazit plný text záznamu