Impact of obesity and leptin levels on the secretion of estradiol, inhibin A and inhibin B during ovarian stimulation with gonadotropins
| Autor: | Nóra Dévényi, K. Klinga, P. Fedorcsák, T. Strowitzki, Thomas Rabe, János Urbancsek, Zoltán Papp |
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| Rok vydání: | 2002 |
| Předmět: |
endocrine system
medicine.medical_specialty endocrine system diseases medicine.drug_class Endocrinology Diabetes and Metabolism medicine.medical_treatment media_common.quotation_subject Luteal phase Follicle-stimulating hormone Endocrinology Internal medicine Follicular phase medicine reproductive and urinary physiology Menstrual cycle media_common business.industry Leptin Obstetrics and Gynecology female genital diseases and pregnancy complications Estrogen Ovulation induction Luteinizing hormone business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Gynecological Endocrinology. 16:285-292 |
| ISSN: | 1473-0766 0951-3590 |
| Popis: | We examined the impact of high leptin levels on the secretion of estradiol, inhibin A and inhibin B in obese and lean women during ovarian stimulation. Patients undergoing long-term pituitary suppression, ovarian stimulation and in vitro fertilization for non-endocrine reasons were included in this case-control study. Obese women (body mass index (BMI) > 28 kg/m(2); n = 17) were individually matched with lean women (BMI 20-25 kg/m(2); n = 17) for age and baseline follicle stimulating hormone and luteinizing hormone concentrations. Blood samples were collected in a previous menstrual cycle and 1-3 days apart throughout ovarian stimulation. Serum levels of estradiol, leptin, inhibin A and inhibin B were measured. Obese and lean women had similar serum concentrations of estradiol, inhibin A and inhibin B in the follicular and luteal phases of the spontaneous menstrual cycle, and throughout ovarian stimulation. Serum levels of leptin were higher in obese than in lean women, and increased during stimulation in both groups. In the obese group, area-under-the-curve (AUC) leptin levels correlated with AUC inhibin A levels. In the lean group, there was no correlation between AUC leptin levels and AUC levels of ovarian hormones. The results suggest that high leptin concentrations in vivo are not associated with impaired secretion of estradiol and dimeric inhibins during ovarian stimulation. |
| Databáze: | OpenAIRE |
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