The effect of St. John’s wort supercritical extract and hyperforin solution on biological subjects

Autor:	A. A. Krutikova, F. D. Lepeshkin, A. L. Drozdov, K. B. Ustinovich, O. O. Parenago, I. A. Beleneva, O. I. Pokrovskii
Rok vydání:	2013
Předmět:	biology Chemistry Cell growth Hypericum perforatum Biological activity biology.organism_classification Sperm Yeast Hyperforin chemistry.chemical_compound Biochemistry biology.animal embryonic structures Physical and Theoretical Chemistry Sea urchin Bacteria
Zdroj:	Russian Journal of Physical Chemistry B. 7:854-862
ISSN:	1990-7923 1990-7931
DOI:	10.1134/s1990793113070063
Popis:	The biological activity of supercritical fluid (SCF) extracts of St. John’s wort and hyperforin solutions isolated from these extracts has been studied relative to both prokaryotic (standard bacteria strains) and eukaryotic (yeast and sea urchin gametes and zygotes). A pronounced toxicity of the hyperforin solution in relation to the blue pus bacillus Pseudomonas aeruginosa was observed. No antimicrobial activity of the same solution with respect to other tested bacteria and yeast was revealed. In addition, the toxicities of both the hyperforin solution and total St. John’s wort SCF extract for sperm cells and zygotes of sea urchin were registered. Addition of the SCF extract to a culture of growing embryos does not affect fertilization and division, but cell development terminates at an early gastrula stage. This indicates that the extract damages the genome transcription process in the zygotes.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::41fc1b2cd15bfde466c974f9f114eda2 https://doi.org/10.1134/s1990793113070063 Zobrazit plný text záznamu Full text from SpringerLink